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Antibiotic Therapy

Systemic Antibiotic Therapy
Low Dose Antibiotics
Local Antibiotic Therapy

Systemic Antibiotic Therapy

Systemic antibiotics are drugs that, when given, affect the whole body. Normally they are administered in pill form when used in periodontal treatment. Periodontists use systemic antibiotics to treat acute infections, such as a gum abscess (gum boil), and also before treatment when patients have certain medical conditions, such as joint and heart valve replacements.  Systemic antibiotics are also recommended after regeneration procedures and when implants are placed. This is done to make sure there is no infection during the early healing stages, which are critical with these two techniques.

As a rule, for most routine periodontal conditions, systemic antibiotics are not necessary.  In some cases there may be very specific harmful bacteria that can be eradicated with oral antibiotics. For these cases, we take a culture and give a short-term treatment of antibiotics specific to kill the bacteria found in the culture. In addition, cases where traditional treatment does not produce the expected results, the mouth may be cultured to find out what specific bacteria are present. This will help guide us on which antibiotic to use. For more information on the microbacteria testing kit, please choose from the following:

Microbacteria Testing Kit Brochure
Results Report

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Low Dose Antibiotics

There has been interest in the use of low dose antibiotics. The dose is so low that the drug does not act to kill bacteria, but rather to change the way the body responds to infection.

One interesting effect of certain antibiotics is they not only kill the bacteria that may cause periodontal disease, but they also reduce the body's production of collagenase, an enzyme that destroys gingival tissues.

We all need some collagenase as older tissue is removed and replaced with new tissue. However, in periodontal disease, there seems to be an overproduction of collagenase, causing the body to destroy healthy gum tissue.

The antibiotic doxycycline was found to combat these enzymes, even in doses so small that there was not an antibiotic effect. The advantage of the smaller doses is a great reduction in the chance of resistant bacterial strains forming.

Periostat is a capsule of 20mg of doxycycline, and clinical studies have shown that patients who take two capsules daily have a reduction in clinical inflammation. The studies were limited to nine months, so there is no official recommendation to take the product for a longer period.

From a practical standpoint, it seems that Periostat can be taken indefinitely. However, some preliminary work indicates that there is a positive residual effect for three months after stopping the drug, so some practitioners recommend taking Periostat three months on, three months off.

The daily 40mg doses are so low as not to qualify as an antibiotic, and there is no known effect on the pocket bacteria. Indications for Periostat are generally seen in recall patients who are not responding well, and have generalized inflammation in spite of reasonable oral hygiene.

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Periostat

 

Local Antibiotic Therapy


Atridox
Arestin

There has been much interest in local antibiotic delivery. If an antibiotic can be delivered directly to the pocket, without the patient having to take oral doses, there are far fewer side effects, and fewer chances of resistant bacteria forming.

In addition, with direct local delivery, the concentration of the antibiotic at the diseased site can be 100 times greater than taking the medication orally. However, it is important to note that all local delivery antibiotics are recommended as adjuncts to scaling and root debridement, and not as stand-alone treatments.

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Systemic Antibiotic Diagram Systemic antibiotics are diluted before reaching the pocket. With local application, the antibiotic is inserted directly into the pocket, resulting in much higher concentrations.

Atridox™ (controlled released doxycycline hyclate, 10%)

Atridox is a registered trademark of Block Drug Corporation.
Atridox is a unique delivery system that uses a gel, which can be injected directly into a pocket. The gel hardens quickly, and then slowly releases the antibiotic over the next seven days. The hardened gel then melts away over time or is gently removed at the office.

The product comes in two syringes, one containing 450mg of a liquid polymer, and the other 50mg of doxycycline hyclate, an antibiotic effective against most periodontal pathogens. The syringes are interlocked together, and the contents mixed vigorously.

syringe containing liquid polymer and doxycycline Syringes containing liquid polymer and doxycycline
mixing contents of the two syringes Mixing contents of the two syringes
inserting canula to prepare for placement Inserting canula (blunt needle) to prepare for placement

Following mixing, a canula is placed on the syringe containing the Atridox, and the material is injected under the gum into the pocket. This generally requires no anesthesia.

atridox being injected in periodontal pocket Atridox being injected into periodontal pocket

Atridox sets rapidly on contact with saliva, and quickly takes on a wax-like consistency. This allows the material to remain in the pocket for seven days, during which time it slowly releases the antibiotic.

The patient should refrain from flossing this area for one week. During that time chlorhexidine mouthwash may be recommended.

 

 

 

 

Studies have shown decreased probing depth, reduced bleeding, and improved attachment levels when Atridox is used in conjunction with scaling and planing.

pocket and bleeding on probing Pocketing and bleeding on probing
pocket reduction and lack of bleeding after atirdox Pocket reduction and lack of bleeding after Atridox

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Arestin

The most recent local antibiotic therapy introduced consists of small spheres of minocycline, a derivative of tetracycline. This drug, similar to the ingredients in Atridox, is very effective in killing the bacteria that are thought to cause periodontal disease.

The primary advantage of this new product is the ease of use. The spheres, which look like a fine powder, are contained in a small blunt plastic tube, and are injected into the pocket. This requires no anesthesia.

The spheres are bioadhesive, and stick to the pocket wall, where they slowly release minocycline over a 14-to-21-day period. Because the spheres are also biodegradable they do not require removal.

syringe containing arestin (minocycline) Delivery syringe containing Arestin (minocycline)
syringe consisting of cap plunger and arestin The plastic syringe consists of a cap, a plunger, and the Arestin, which is expelled by the plunger
closeup of arestin powder being expelled from syringe Close-up of Arestin powder being expelled from syringe tip
arestin being expelled under the gum and into periodontal pocket Arestin being expelled under the gum and into the periodontal pocket

 

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